Get Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), PDF

By Taotao Zou

This thesis makes a speciality of the improvement of gold- and non-classical platinum-based anti-cancer brokers that exhibit distinctively diverse anti-cancer mechanisms in comparison to the widely used cisplatin. those steel complexes comprise N-heterocyclic carbene (NHC) ligands that are in a position to shape robust M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. designated chemical synthesis, in vitro and/or in vivo anti-cancer actions are in actual fact offered together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that at the same time act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) advanced with a combined diphosphine and bis(NHC) ligand showing favorable balance and exhibiting major inhibition of tumor progress in self sustaining mice types without observable unwanted side effects; and (iii) a panel of sturdy luminescent cyclometalated platinum(II) complexes displaying excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER tension and cellphone apoptosis. those works spotlight the scientific power that gold and platinum complexes supply for melanoma treatment.

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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) by Taotao Zou


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